Bioproduction – Trichome Protein Factories

Over the past few decades, discoveries in plant biology have enabled the production of heterologous proteins in plants and have opened the possibility to produce high-value proteins that are too difficult or costly to make in other systems. Plant-based protein expression systems are environmentally-friendly production methods with unlimited scalability. At PhylloTech, we use patented technology to produce high-value proteins such as antibodies and enzymes in plant trichomes.

Biopesticide Pipeline – Enzymes in Ag


PhylloTech’s core technology is based on our discovery that some plants secrete defensive proteins termed phylloplanins. This novel family of secreted plant proteins inhibit a broad range of agricultural pathogens. Our scientists have published reports on phylloplanin effectiveness and the results of their endeavors are clear: phylloplanins are extremely effective, broad-spectrum pathogen controls. We believe these antimicrobial proteins are the next generation of environmentally-friendly biofungicides and genetic crop traits to enhance disease resistance.


Quorum sensing is a biochemical process that allows bacterial populations to coordinate gene expression and plays a significant role in the onset of pathogenesis and biofilm development. Using Acylases, PhylloTech is currently developing environmentally-friendly methods to interrupt this process and limit the ability of bacterial pathogens to cause crop diseases.

Team Members

Ryan Shepherd
Ryan W. Shepherd, Ph.D., is Chief Executive Officer and co-founder of PhylloTech, Inc. His activities include business development, scientific R&D, fundraising, technology licensing, intellectual property, global collaborations, and management of both scientific and business personnel. Ryan holds a B.A. in Organismal Biology from Beloit College (Beloit, WI) and a Ph.D. in Plant Biochemistry and Molecular Biology from the University of Kentucky (Lexington, KY). He was a National Science Foundation Postdoctoral Fellow at the University of California-Berkeley.
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Colin Shepherd
Colin Shepherd, Ph.D., MBA, is Chief Operating Officer and co-founder and manages new product development and commercialization. He identifies new opportunities and guides technical and business development on current products. He also leads new product launches and conceptualizes strategies on company operations, technology positioning, IP, and R&D. He received his Ph.D. and M.B.A. from Iowa State University and has 8 years of experience in management functions at diverse biotechnology companies, including AimsBio Inc., where he was founder and CEO, and at Siva Therapeutics Inc., where he was Chief Financial Officer.
Steve Lindow
Scientific Advisor
Steven E. Lindow, Ph.D.; Professor, Executive Associate Dean, College of Natural Resources, University of California-Berkeley. Professor Steven Lindow is a world-renowned scientist who specializes in phyllosphere microbiology and microbial ecology with an emphasis on ice nucleation active bacteria. He obtained his Ph.D. in Plant Pathology from UW-Madison in 1977. Professor Lindow has been at UC-Berkeley for over 35 years and he has authored over 200 publications. He was elected to the National Academy of Sciences in 1999 and is a Fellow of the American Association for the Advancement of Science, the American Academy of Microbiology, and the American Phytopathological Society.
Silke Robatzek
Scientific Advisor
Silke Robatzek Ph.D.; Professor, The Sainsbury Laboratory, Norwich UK. Professor Robatzek is a well-known scientist who specializes in plant-microbe interactions. Her current work elucidates the mechanisms by which plants transport proteins in response to pathogen attack, and identifies the biochemical cargoes and molecular switches involved in transport-regulated plant immunity. She also studies the cellular transport pathways that are modulated by pathogen attack, and has authored numerous publications in leading plant science and plant pathology journals.
Julian Schroeder
Scientific Advisor
Julian Schroeder Ph.D.; Professor, University of California San Diego. Studied at the Max Planck Institute for Biophysical Chemistry with Erwin Neher and was a von Humboldt postdoctoral fellow at UCLA School of Medicine. He received awards, including the Presidential Young Investigator Award (NSF), the ASPB Charles Albert Shull Award (1997), a DFG Heinz-Maier-Leibnitz Prize, the Blasker Award in Environmental Science, is Churchill Overseas Fellow at Cambridge University and with collaborators shared the Cozzarelli Prize from PNAS (2010) and a top 10 breakthrough of the year selected by Science (2009). He is a member of the U.S. National Academy of Sciences and Fellow of the American Association for the Advancement of Science.
Cassandra Brzycki
Associate Scientist
Cassandra is a graduate of the University of Wisconsin-Madison, with bachelor's degrees in chemical engineering and biochemistry. As an undergraduate, she worked on performing metabolic engineering of E. coli for biodiesel production. She has also held several industrial research and development positions, including a co-op at a corn ethanol plant and a molecular biology internship with the Wisconsin Crop Innovation Center.
Claire Scott
Associate Scientist
Claire graduated from the University of Wisconsin-Madison with a degree in Genetics. She has experience through a variety of lab positions at the university and with a summer internship growing skills in plant breeding. She also competed for the Wisconsin Women’s Rowing and is involved in the UW-Madison Association of Women in Agriculture.

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