PhylloTech, Inc. (Middleton, WI) announces that it has developed a new protein production system in plants, based on research funded by the National Science Foundation. The company utilizes tobacco trichomes as continuous production factories that can secrete nearly pure proteins and antibodies to leaf surfaces. The proprietary system can manufacture proteins and antibodies at a reduced cost compared to other systems. See a recent NSF article highlighting the system here.
“Our continuous trichome production system is a new and alternative strategy for protein manufacturing, especially for antibodies and other targets that are expensive or difficult to make in other systems,” said Ryan Shepherd, co-founder and CEO. “Our goal is to help customers realize protein targets in a more cost-sensitive way, with a robust system that is easier to scale and can avoid the tremendous capital costs associated with scalability. Leaf trichomes are natural factories for protein purification, and our work has been focused on increasing their output as well as scale. By utilizing bioengineered plants in this way, we believe we have developed a great system to help customers make antibodies and other proteins, therapeutic or otherwise, in a manner that could have broad reaching implications on the costs of these products.”
PhylloTech, Inc. was opened in 2010 at University Research Park (Madison, WI) by plant scientists and entrepreneurs Ryan Shepherd PhD and Colin Shepherd PhD, MBA, and is now based in a larger facility in Middleton, WI. Since that time, the company has received over $2.4M in federal SBIR grants to perform R&D on difficult problems in plant biotechnology. In addition to its protein production system in plants, the company is also developing novel antifungal and antibacterial biopesticides which are available for partnerships.
For more information and to contact PhylloTech, please visit www.phyllotech.com.
Biopesticide developer and plant biotechnology company PhylloTech, LLC announces that it has opened a new headquarters in Middleton, WI. The company also announces that it has received a 2-year, $750,000 Phase II Small Business Innovation Research (SBIR) grant from the National Science Foundation (NSF). Continue reading PhylloTech opens new Middleton, WI headquarters and receives additional NSF grant funds
PhylloTech, LLC (Madison, WI) announces that it has been selected to present at the 2016 Ag Innovation Showcase in St. Louis, MO. This premier event, to be held on September 12-14, 2016, is an outstanding opportunity for emerging companies to introduce their technologies to investors and strategic partners. More information can be found at www.agshowcase.com.
August 26, 2015
PhylloTech, LLC (Madison, WI) announces that it has been awarded a $500,000 Phase II Small Business Innovation Research (SBIR) grant to continue work on new technologies that could be utilized to curb plant diseases. “This project will allow us to expand our development of enzymatic products to control bacterial pathogens in agriculture,” stated Ryan W. Shepherd, Ph.D., the company’s CEO and Project Director for the grant. “We’re essentially disorienting pathogens so that they do not cause disease.”
The popularity of environmentally-friendly biopesticides among consumers is rapidly increasing. PhylloTech received the 2-year Phase II grant through the very competitive SBIR program at the United States Department of Agriculture-National Institute of Food and Agriculture (USDA-NIFA). “The technical concepts underlying this project originated from my postdoctoral fellowship in California, so this grant is personally rewarding and exciting to see commercialized,” said Shepherd. “We’re developing commercial biodeterrents that can be used to control disease on many different crops without adverse impacts on the environment.” The USDA-NIFA grant funding will be used to scale-up production, perform field trials against numerous bacterial pathogens, and initiate product registration. PhylloTech is an agricultural biotechnology company that is developing antibody bioproduction systems in plants and innovative strategies for disease control. Please visit www.phyllotech.com for further information.
April 22, 2015. PhylloTech, LLC (Madison, WI) announces that it will exhibit at the 2015 Biotechnology Industry Organization (BIO) International Meeting in Philadelphia, PA from June 15-18, 2015. The company was selected by the National Science Foundation (NSF) to host a kiosk in the Innovation Zone, an area of the exhibition floor that is dedicated to showcasing Small Business Innovation Research (SBIR) grantees. Please contact Ryan Shepherd or Danielle Wittenwyler through the One-on-One Partnering System at the BIO Conference website if you would like to schedule a meeting at BIO 2015.
PhylloTech, LLC (Madison, WI) announces that Ryan Shepherd, CEO, will present at the 2015 Angel Capital Association Summit (ACA) in San Diego, CA. PhylloTech is one of only eight companies selected and sponsored by the National Science Foundation to participate in the “Innovation Showcase.” The ACA Summit, to be held April 14-16, will bring together more than 700 investment leaders, including angel investors and angel groups, accredited platforms, and support providers.
PhylloTech, LLC (Madison, WI) announces that it has been awarded a $200,000 RAPID Small Business Innovation Research (SBIR) grant from the National Science Foundation (NSF). The company will use their plant bioproduction platform to generate and secrete antibodies in a manner that avoids extraction and purification costs. “We are excited to apply our technology to the therapeutic antibody market,” said Danielle Wittenwyler, Ph.D., R&D Manager at PhylloTech. “Our platform could redefine antibody production with sustainable manufacturing practices and minimized costs.”
“Antibodies are used as everyday research tools and to diagnose and treat a spectrum of diseases that includes cancer, lethal viruses, and asthma,” said Ryan Shepherd, Ph.D., PhylloTech’s Chief Executive Officer. “Antibody production is an excellent application of our technology and we could have an enormous impact on the treatment of current and emerging diseases.” PhylloTech is an agricultural biotechnology company that is also developing innovative strategies for plant disease control. PhylloTech is headquartered at the University Research Park in Madison, WI. Please visit www.phyllotech.com for further information.
Chemical Engineering Progress recently featured PhylloTech’s production system in the article “Living Plants: One-Stop Shop for Protein Manufacturing” as part of the Catalyzing Commercialization series. This article was prepared by NSF for AlChE and appeared in the July 2014 issue of CEP. For the full article, go to: http://www.aiche.org/sites/default/files/cep/20140712.pdf
PhylloTech will host a CrossRoads in AgBiotech Seminar on November 7th at the University of Wisconsin-Madison Campus. Steve Lindow, a professor in the Plant & Microbial Biology Department at the University of California–Berkeley, will be speaking on the interactions of bacteria with plants and fungi on the leaf surface at 11 a.m. in the Ebling Symposium Center of the UW Microbial Sciences Building (1550 Linden Drive; Madison, WI). A presentation abstract and additional information are available here: www.phyllotech.com/crossroadsagbiotech.
August 20, 2014. Scientists from PhylloTech, LLC (Madison, WI), in collaboration with researchers from the University of Wisconsin-Madison, have published a paper in the August issue of Plant Health Progress, a multidisciplinary science journal by the American Phytopathological Society. The paper, entitled “A microfluidic assay for identifying differential responses of plant and human fungal pathogens to tobacco phylloplanins,” characterizes the broad-spectrum efficacy of tobacco phylloplanins against the fungal pathogens Aspergillus fumigatus and Colletotrichum coccodes. A summary and link to the full paper can be found here.